q-bio.BM · 2026-08-12 · No. 82

Biomolecules, 2026-08-12.

1 new papers in q-bio.BM. Titles, authors, abstracts. Links to arXiv. Want this in your inbox every morning? Subscribe →

01 — The papers

1 entries
  1. 01

    DegradeQuery: Counterfactual Tuple Pretraining for Context-Aware PROTAC Degradation Prediction

    Dong Xu, Zhangfan Yang, Jiantao Wu, Zexuan Zhu, Jianqiang Li, Junkai Ji

    q-bio.BM · cs.AI

    Proteolysis-targeting chimeras (PROTACs) induce protein degradation by recruiting a target protein to an E3 ubiquitin ligase, making degradation a joint outcome of the degrader molecule and its biological context. Although public databases contain thousands of structured molecule-target-E3 records, degradation measurements are available for only a small fraction of them. Existing supervised approaches therefore leave most recorded...

    arxiv.org/abs/2608.10595 · PDF

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