q-bio.BM · 2026-08-27 · No. 97
Biomolecules, 2026-08-27.
1 new papers in q-bio.BM. Titles, authors,
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01 — The papers
1 entries-
01
A meta-algorithm for ab initio reconstruction of complex mixtures in cryo-EM
Alkin Kaz, Arda Kaz, Ellen D. Zhong
q-bio.BM · cs.LG
We describe a systematic approach for spawning and aggregating multi-class cryo-EM reconstruction jobs. This approach formalizes standard ad hoc strategies of iterative classification and filtering typically used by practitioners to sort impure, heterogeneous samples. To our knowledge, this is the first method that can successfully perform ab initio reconstruction on datasets containing dozens of distinct species. We obtain 97% accuracy on ab...
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