q-bio.GN · 2026-06-09 · No. 18
Genomics, 2026-06-09.
1 new papers in q-bio.GN. Titles, authors,
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01 — The papers
1 entries-
01
Integrating gene regulatory priors into Transformer attention with scTransformer for interpretable scRNA-seq analysis
Mikele Milia, Louis Fabrice Tshimanga, Henning Mueller, Manfredo Atzori, Barbara Di Camillo
q-bio.GN · cs.LG
Motivation: Transformer-based models are increasingly applied to large-scale single-cell transcriptomics, showing strong performance through self-supervised learning on millions of cells. However, most existing approaches treat genes as independent features, and largely ignore prior biological knowledge, which limits interpretability and robustness. In this paper, we explore whether explicitly incorporating gene regulatory information can...
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