q-bio.QM · 2026-06-11 · No. 20

Quantitative Methods, 2026-06-11.

1 new papers in q-bio.QM. Titles, authors, abstracts. Links to arXiv. Want this in your inbox every morning? Subscribe →

01 — The papers

1 entries
  1. 01

    Seeing Below the Limit of Detection: A Censored-Poisson Bayesian Latent-Growth Change-Point Detector (the Span Detector) for Serial ctDNA in HR+/HER2- Metastatic Breast Cancer

    Aarchi Singh Thakur, Abhijoy Sarkar

    q-bio.QM · cs.LG · stat.ME

    Circulating-tumour DNA (ctDNA) carries evidence of drug resistance months before imaging shows it, but the earliest evidence lives below the assay's limit of detection (LoD): a nascent subclone is detected only intermittently, producing a flickering sequence of faint detects and non-detects. Commercial liquid biopsies treat each draw as an independent snapshot and a non-detect as nothing. We argue a non-detect is a left-censored observation,...

    arxiv.org/abs/2606.11876 · PDF

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